OA 200 mg daily as a single dose or in 2 divided doses or 200 mg bid if necessary. RA 100-200 mg bid.Ankylosing spondylitis Initially 200 mg daily as a single dose or in 2 divided doses. May be increased to 400 mg daily after 6 wk; consider alternative treatment if no response after further 6 wk. Pain & dysmenorrhea Initially 400 mg followed by an additional 200 mg if necessary on the 1st day; thereafter 200 mg bid. Adjunctive therapy to reduce the number of adenomatous colorectal polyps in patient w/ familial adenomatous polyposis 400 mg bid.
History of ischaemic heart or cerebrovascular disease. Patients w/ significant risk factors for CV disease or peripheral arterial disease. Dehydrated patients.
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