Choriogonadotropin alfa


Generic Medicine Info
Indications and Dosage
Subcutaneous
Controlled ovarian hyperstimulation for assisted reproduction in infertility, Female infertility of anovulatory origin
Adult: 250 mcg as a single dose 1 day after the last dose of follicle stimulating agent. Administer only after sufficient follicular development has been determined (as indicated by serum estradiol and vaginal ultrasonography).
Contraindications
Primary ovarian failure; hypothalamus or pituitary gland tumours; ovarian cyst or enlargement unrelated to polycystic ovarian syndrome (PCOS), gynaecological haemorrhages of unknown origin; mammary, ovarian, or uterine carcinoma or sex hormone dependent tumours of the reproductive tract and accessory organs; ectopic pregnancy in the past 3 months, active thromboembolic disorders, fibroid tumours of the uterus or malformation of sexual organs incompatible with pregnancy, uncontrolled thyroid or adrenal dysfunction. Postmenopausal women. Pregnancy.
Special Precautions
Patient with PCOS; history of tubal disease; recent thromboembolic disease or risk factors for thromboembolic events (e.g. personal or family history). Not indicated for other conditions such as corpus luteum insufficiency or male conditions. In women being treated for anovulatory infertility, it is recommended to have coitus on the day of and the day after receiving choriogonadotropin alfa inj. Lactation.
Adverse Reactions
Significant: Ovarian hyperstimulation syndrome (OHSS), ovarian enlargement; thromboembolic events; multiple births, pregnancy loss by miscarriage or abortion, ectopic pregnancy, premature labour, postpartum fever, congenital malformations, neoplasms of the ovary and other reproductive system (benign and malignant).
Gastrointestinal disorders: Nausea, vomiting, abdominal pain, distension, or discomfort, diarrhoea.
General disorders and administration site conditions: Inj site reactions.
Nervous system disorders: Headache.
Parenteral/SC: X
Monitoring Parameters
Perform thorough gynaecologic and endocrinologic evaluations, and evaluate for hypothyroidism, adrenocortical deficiency, hyperprolactinaemia, pituitary or hypothalamic tumours before therapy. Assess the fertility potential of the male sexual partner (e.g. semen analysis) during initial evaluation. Confirm pregnancy status before initiating therapy. Obtain ultrasound and/or estradiol levels to evaluate follicle development. Assess ovulation (e.g. basal body temperature, menstruation, serum progestin level). Monitor for signs and symptoms of OHSS (e.g. gastrointestinal symptoms, severe ovarian enlargement, weight gain, dyspnoea, oliguria).
Lab Interference
May interfere with the immunological determination of serum or urinary hCG which may lead to false positive pregnancy test; interference may last for up to 10 days. May cross-react in the radioimmunoassay of LH and other gonadotrophins.
Action
Description: Choriogonadotropin alfa is a recombinant form of chorionic gonadotrophin that binds to LH/hCG receptor of the ovarian granulosa and theca cells in the absence of an endogenous LH surge. It stimulates late follicular maturation of the ovarian follicle and resumption of oocyte meiosis, and initiates the rupture of the pre-ovulatory ovarian follicle.
Pharmacokinetics:
Absorption: Bioavailability: Approx 40%. Time to peak plasma concentration: 12-24 hours.
Distribution: Volume of distribution: 21.4 L.
Excretion: Via urine (10%). Terminal elimination half-life: Approx 30 hours.
Storage
Pre-filled pen/syringe: Store between 2-8°C. Do not freeze. Pre-filled syringe may also be stored at ≤25°C for up to 30 days. Protect from light.
MIMS Class
Trophic Hormones & Related Synthetic Drugs
ATC Classification
G03GA08 - choriogonadotropin alfa ; Belongs to the class of gonadotropins. Used as ovulation stimulants.
References
Anon. Choriogonadotropin Alfa. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 02/11/2021.

Anon. Chorionic Gonadotrophin [Chorionic Gonadotropin] (Recombinant). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 02/11/2021.

Buckingham R (ed). Chorionic Gonadotrophin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/11/2021.

Joint Formulary Committee. Choriogonadotropin Alfa. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/11/2021.

Ovidrel 250 mcg/0.5 mL Solution for Injection in Pre-Filled Syringe or Pre-Filled Pen (Merck Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 02/11/2021.

Ovidrel Injection, Solution (EMD Serono, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 02/11/2021.

Ovitrelle 250 mcg Solution for Injection in Pre-Filled Pen (Merck Serono Ltd). MHRA. https://products.mhra.gov.uk. Accessed 02/11/2021.

Disclaimer: This information is independently developed by MIMS based on Choriogonadotropin alfa from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by MIMS.com
  • Ovidrel
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