Chymotrypsin


Concise Prescribing Info
Indications/Uses
Enzymatic zonulysis for intracapsular lens extraction.
Dosage/Direction for Use
Adult : Intraocular Irrigate the posterior chamber with 1-2 mL of a 1:5,000 diluted soln. Then irrigate with at least 2 mL of the unused portion of the diluent 2-4 mins after procedure.
Dosage Details
Intraocular
Enzymatic zonulysis for intracapsular lens extraction
Adult: Irrigate the posterior chamber with 1-2 mL of a 1:5000 diluted soln (150 N.F.u/mL). Then irrigate with at least 2 mL of the unused portion of the diluent 2-4 min after procedure.
Contraindications
Hypersensitivity. High vitreous pressure & a gaping incisional wound, congenital cataracts, patients < 20 yr due to probable lens-vitreous adhesion not responsive to α-chymotrypsin lysis.
Adverse Reactions
IM: Occasionally, severe allergic reactions. Ophthalmological: Increased intraocular pressure, corneal oedema, striation & moderate uveitis.
Action
Description: Chymotrypsin is a proteolytic enzyme obtained by the activation of chymotrypsinogen extracted from the pancreas of beef that has been used in ophthalmology for the dissection of the zonule of the lens, thus facilitating intracapsular cataract extraction & reducing trauma to the eye. It has also been given for its anti-inflammatory actions eg, in soft-tissue inflammation & oedema.
Disclaimer: This information is independently developed by MIMS based on Chymotrypsin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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