Ciclodin IV

Ciclodin IV



Siu Guan Chem


JustRight Healthcare
Full Prescribing Info
Ciprofloxacin hydrochloride.
Each mL contains Ciprofloxacin 2 mg (as hydrochloride).
For the treatment of wide range of infections including anthrax, biliary tract infections, infected bites and stings, bone and joint infections, cat scratch disease, chancroid, exacerbations of cystic fibrosis, gastroenteritis (traveller's diarrhoea, campylobacter enteritis, cholera, salmonella enteritis, shigellosis), gonorrhoea, neutropenia, legionnaire's disease, otitis externa, otitis media, peritonitis, Q, fever, lower respiratory tract infections (pseudomonal infections in cystic fibrosis), septicaemia, skin infections (soft-tissue infections), spotted fevers, typhoid and paratyphoid fever, typhus and urinary-tract infections. Used also as prophylaxis for meningococcal meningitis and surgical infections.
Dosage/Direction for Use
Adult: 100 mg to 400 mg twice daily, given over 30 to 60 minutes as a solution containing the equivalent of 1-2 mg/mL.
Children: 4-8 mg/kg twice daily is suggested.
10 mg/kg twice daily up to maximum of 400 mg twice daily (for exacerbation of cystic fibrosis associated with Pseudomonas aeruginosa infection).
Not generally recommended for other uses in children and adolescents unless considered essential or as prescribed by the physician.
Contraindicated to some patients who experience tendon pain, inflammation or rupture and the treatment should be discontinued to prevent tendon damage.
Special Precautions
Ciprofloxacin should be used with caution in patients with epilepsy or a history of CNS disorders. Should not be used in children, adolescents. Pregnant women, or breastfeeding mothers or use only if the benefits outweighs the risk.
Use In Pregnancy & Lactation
Use with caution in pregnant women or breastfeeding mothers or use only if the benefits outweighs the risk.
Adverse Reactions
Ciprofloxacin is generally well tolerated. Gastrointestinal disturbances include nausea, vomiting, diarrhoea, abdominal pain, and dyspepsia are the most frequent side effects. Pseudomembranous colitis has been reportedly rarely. The most common on the CNS are headache, dizziness, restlessness, drowsiness, insomnia, nightmares and other sensory disturbances. More rarely, hallucinations, psychotic reactions, depression and convulsions. Rash, pruritus, hypersensitivity-type reactions have been included rarely, vasculitis, erythema multiforme, Steven-Johnsons syndrome, and toxic epidermal necrolysis. Anaphylaxis, transient increase in serum creatinine or blood urea nitrogen and occasionally actual renal failure, interstitial nephritis, crystalluria; elevated liver enzyme values, jaundice and hepatitis; haematological disturbances including haemolytic anemia, or agranulocytosis; myalgia; gynaecomastia and sweating. Pain and irritation may occur at the site of injection accompanied rarely by thrombophlebitis.
Drug Interactions
Aluminum, magnesium or iron reduces absorption of Ciprofloxacin. It also decreases the clearance of theophylline, increases blood concentrations of midazolam according to some isolated reports. The urinary excretion of Ciprofloxacin reduced by probenecid. When used simultaneously with azlocillin, it has resulted in higher and more prolonged concentration of Ciprofloxacin. Changes in pharmacokinetics of fluoroquinolones such as Ciprofloxacin have been reported when given with histamine H2 antagonist, possibly due to the change in gastric pH, but do not seem to be of much of clinical significance.
Theophylline interferes with metabolism of caffeine, enhances effects of oral anticoagulants warfarin, glibenclamide, probenecid, metoclopramide and its derivatives.
Keep at temperatures not exceeding 30°C.
MIMS Class
ATC Classification
J01MA02 - ciprofloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
Soln for IV infusion (vial) 2 mg/mL x 100 mL x 1's.
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