Except under special circumstances, this medication should not be used when the following medical problems exist: Previous allergic reaction or hypersensitivity to fluoroquinolones or other chemically related quinolone derivatives.
History of tendinitis or tendon rupture (Fluoroquinolones have been reported to cause tendinitis or tendon rupture during or after treatment; other fluoroquinolones are not recommended for patients with these problems).
Risk-benefit should be considered when the following medical problems exist: Cerebral arteriosclerosis; Epilepsy; Other factors that predispose to seizures (Fluoroquinolones may cause CNS stimulation or toxicity; convulsions may occur within 3 to 4 days after the start of fluoroquinolone treatment and usually resolve with discontinuation of the fluoroquinolone; Fluoroquinolones should be used with caution in patients with confirmed or suspected CNS disorders).
Hepatic function impairment (patients with severe hepatic function impairment, such as cirrhosis with ascites, resulting in an increase in peak serum concentration and elimination half-life; patients with both hepatic and renal function impairment may require a reduction in the dosage of Ciprofloxacin).
Renal function impairment (in general, fluoroquinolones primarily are excreted renally; it is recommended that patients with impaired renal function be administered reduced doses of fluoroquinolones).