Cilostan CR

Cilostan CR

cilostazol

Manufacturer:

Korea United Pharma

Distributor:

Pharma 3
Concise Prescribing Info
Contents
Cilostazol
Indications/Uses
Improvement of the maximal & pain-free walking distances in patient w/ intermittent claudication who do not have rest pain & evidence of peripheral tissue necrosis. 2nd line use in patient whom lifestyle modifications & other appropriate interventions have failed to sufficiently improve their intermittent claudication symptoms.
Dosage/Direction for Use
Administration
Should be taken on an empty stomach: Take at least 30 min before or 2 hr after meals.
Contraindications
Hypersensitivity. Known predisposition to bleeding (eg, active peptic ulceration, haemorrhagic stroke, proliferative diabetic retinopathy, poorly controlled HTN). CHF. Women of childbearing potential. Pregnancy.
Special Precautions
Patients using anticoagulants (eg, warfarin), platelet aggregation inhibitor including aspirin, ticlopidine & thrombolytics including urokinase & alteplase; prostaglandin E1 or derivative (alprostadile, rimaprodex, alphadex). Patients w/ menstruation. Severe renal impairment (CrCl ≤25 mL/min). Moderate or severe hepatic impairment. Known predisposition to bleeding (eg, active peptic ulceration, haemorrhagic stroke, proliferative diabetic retinopathy, poorly controlled HTN). History of ventricular tachycardia, ventricular fibrillation or multifocal ventricular ectopics; prolongation of QTc interval. Report any episode of bleeding or easy bruising; early development of dyscrasia. May cause dizziness affecting ability to drive or operate machinery. Pregnancy & lactation. Elderly.
Adverse Reactions
Encephalorrhagia, pneumorrhagia, fundus bleeding, nasal hemorrhage, hematuria. Pancytopenia, agranulocytosis. Interstitial pneumonia accompanied w/ flush, cough, dyspnea, disorder of chest, eosinophilia. CHF, cardiac infarction, angina pectoris, ventricular tachycardia.
Drug Interactions
May cause bleeding w/ anticoagulants eg, warfarin; platelet aggregation inhibitors eg, aspirin, ticlopidine & thrombolytics including urokinase & alteplase; prostaglandin E1 or derivatives (alprostadile, rimaprodex, alphadex). May increase blood levels w/ CYP3A4 inhibitors (erythromycin, cimetidine, grapefruit juice; omeprazole); organic of CYP3A4 (diltiazem).
MIMS Class
Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)
ATC Classification
B01AC23 - cilostazol ; Belongs to the class of platelet aggregation inhibitors excluding heparin. Used in the treatment of thrombosis.
Presentation/Packing
Form
Cilostan CR tab 200 mg
Packing/Price
30's (P2,541/box)
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