Serious Adverse Effects:
Encephalorrhagia, pneumorrhagia, fundus bleeding, occasionally, suffusion, or rarely enteral bleeding, nasal hemorrhage, hematuria may occur. If they occur, the administration should be discontinued and appropriate treatment must be done.
Pancytopenia, agranulocytosis, rarely thrombocytopenia may occur. If they occur, the administration should be discontinued and appropriate treatment must be done.
Interstitial pneumonia, accompanied with flush, cough, dyspnea, disorder of chest, eosinophilia may occur. If these symptoms occur, the administration should be discontinued and appropriate treatment must be done including adrenocortical hormone therapy.
Congestive heart failure, cardiac infarction, angina pectoris, ventricular tachycardia, etc. have been reported. If they occur, the administration should be discontinued and/or appropriate therapy instituted.
Occasionally, elevations of AST, ALT, ALP, LDH and icterus may occur, patients should be observed sufficiently. If any symptoms occur, the administration should be discontinued or reduced.
Occasionally eruption, or rarely epidermatomycosis, urticaria, itch, photosensitivity reaction may occur. If they occur, the administration should be discontinued.
Arrhythmia such as arterial fibrillation, ventricular tachycardia, premature ventricular contraction, decline blood pressure, occasionally, frequent pulse, ardor, and rarely blood pressure increase may occur. If they occur, dose reduction or discontinuation can be considered.
Tremors, occasionally headache, dizziness, or rarely, insomnia, drowsiness may occur. If they occur, the administration should be taken such as dose reduction or discontinuation.
Abdominal pain, nausea, vomiting, anorexia, diarrhea may occur occasionally, or brash, abdominal inflation may occur rarely.
Increases of BUN, creatinine, uratic value may occur rarely.
Hemic and Lymphatic:
Anemia, ecchymosis, iron deficiency anemia, polycythemia, purpura.
Metabolic and Nutritional:
Increased creatinine, gout, hyperlipemia, hyperuricemia.
Arthralgia, bone pain, bursitis.
Anxiety, insomnia, neuralgia.
Asthma, epistaxis, hemoptysis, pneumonia, sinusitis.
Skin and Appendages:
Dry skin, furunculosis, skin hypertrophy, urticaria.
Amblyopia, blindness, conjunctivitis, diplopia, ear pain, eye haemorrhage, retinal haemorrhage, tinnitus.
Albuminuria, cystitis, urinary frequency, vaginal haemorrhage, vaginitis.
Pyrexia, occasionally, sweating, edema or rarely, increment blood sugar, chest pain, tinnitus, dolorific, malaise, conjunctivitis, urinary frequency may occur.