Cimex

Cimex

cefuroxime

Manufacturer:

Multicare

Distributor:

Zuellig
Concise Prescribing Info
Contents
Cefuroxime (tab/susp: axetil; inj: Na)
Indications/Uses
Treatment of susceptible infections eg, bronchitis, gonorrhea, meningitis, otitis media, peritonitis, pharyngitis, sinusitis; skin, bone & joint infections, UTI. Inj: Surgical infection prophylaxis.
Dosage/Direction for Use
Tab Adult Pharyngitis/tonsillitis, acute sinusitis 250-500 mg bid. Acute bronchitis, acute exacerbation of chronic bronchitis, skin infections 250-500 mg bid. Uncomplicated gonorrhea 1 g as single dose. Uncomplicated UTI 125 mg or 250-500 mg bid. Susp Adult 5-10 mL bid. Childn >2 yr 5 mL or 15 mg/kg bid. Max: 10 mL daily; >3 mth 2.5 mL or 10 mg/kg bid. Max: 5 mL daily. Inj Adult 750 mg IV/IM 8 hrly. Severe infections 1.5 g IV 8 hrly or IV/IM 6 hrly. Max: 3-6 g/day. Infant & childn 30-100 mg/kg IV/IM in 3 or 4 divided doses daily. Neonate 30-100 mg/kg IV/IM in 2 or 3 divided doses daily. Gonorrhea 750 mg IM into each buttock. Perioperative prophylaxis Abdominal, pelvic, orthopedic surgery: 1.5 g IV prior to procedure, may be supplemented by 750 mg IM after 8 & 16 hr. Heart, lungs, esophageal, blood vessel surgery: 1.5 g IV prior to procedure, may be supplemented by 750 mg IM 8 hrly for up to 24-48 hr. Total joint replacement 1.5 g powd may be mixed w/ methylmethacrylate cement before adding to liqd monomer. Meningitis Adult 3 g IV 8 hrly. Infant & childn 200-240 mg/kg IV in 3-4 divided doses daily, may be reduced to 100 mg/kg daily. Neonate 100 mg/kg IV, may be reduced to 50 mg/kg daily.
Administration
FC tab: May be taken with or without food. Powd for oral susp: Should be taken with food.
Contraindications
Hypersensitivity to cephalosporins. Inj: History of shock.
Special Precautions
Hypersensitivity to penicillins & β-lactam antibiotics. Prolonged use. Pregnancy & lactation. Tab: Jarisch-Herxheimer reactions in Lyme disease. Consider diagnosis of pseudomembranous colitis in patients who develop diarrhea. Concurrent use w/ potent diuretics. Susp: History of allergy; renal impairment. Monitor renal hematological status especially during prolonged & high-dose therapy. Inj: Personal or family history of allergic symptoms eg, bronchial asthma, exanthema, urticaria. Severe renal disorder; poor oral ingestion, parenteral nutrition, poor general conditions. Perform hepatic & renal function, blood tests at regular intervals during treatment. False +ve results w/ Fehling's, Clinitest & direct Coombs' test. Elderly. Neonate. Tab/Inj: False +ve reaction w/ copper reduction (Benedict's test).
Adverse Reactions
GI disturbances (diarrhea, nausea, vomiting), headache. Inj: Pruritus, shivering, exanthema, fever, urticaria, lymph node tumidity, arthrodynia, anaphylactic reaction. Severe renal disorder.
Drug Interactions
Tab/Susp: Probenecid. Inj: Furosemide diuretics & aminoglycosides.
MIMS Class
Cephalosporins
ATC Classification
J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
Presentation/Packing
Form
Cimex FC tab 500 mg
Packing/Price
50's (P68/film-coated tab)
Form
Cimex powd for oral susp 125 mg/5 mL
Packing/Price
50 mL x 1's (P313.5/bottle);70 mL x 1's (P399/bottle)
/philippines/image/info/cimex powd for oral susp 125 mg-5 ml/125 mg-5 ml x 70 ml?id=2b2ebb75-87ae-4f77-9765-a284009d4cad
/philippines/image/info/cimex powd for oral susp 125 mg-5 ml/125 mg-5 ml x 50 ml?id=d67969ce-5b62-427e-94d2-a284009d4cad
Form
Cimex powd for oral susp 250 mg/5 mL
Packing/Price
50 mL x 1's (P475/bottle)
Form
Cimex powd for inj 1.5 g
Packing/Price
10 × 1's (P561/vial);1's (P561/vial)
Form
Cimex powd for inj 750 mg
Packing/Price
10 × 1's (P330/powd for inj);1's (P330/powd for inj)
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