The patient's pre-treatment body weight should be obtained for calculation of correct dosage. Amikacin may be given intramuscularly or intravenously.
Intramuscular Administration for patients with Normal Renal Function: Recommended dosage for adults, children and other infant: 15 mg/kg/day divided into 2 to 3 equal doses administered at equally divided intervals i.e., 7.5 mg/kg every 12 hours or 5 mg/kg every 8 hours. Treatment of patients in the heavier weight classes should not exceed 1.5 g/day. When amikacin is indicated in newborns, it is recommended that a loading dose of 10 mg/kg, be administered initially to be followed with 7.5 mg/kg every 12 hours.
The usual duration of treatment is 7 to 10 days. It is desirable to limit the duration of treatment to short term whenever feasible.
Intramuscular Administration for patients with Impaired Renal Function: Whenever possible, serum amikacin concentrations should be monitored by appropriate assay procedures.
Doses may be adjusted in patients with impaired renal function either by administering normal doses at prolonged intervals or by administering reduced doses at a fixed intervals.
Intravenous Administration: The individual dose, the total daily dose, and the total cumulative dose of Amikacin are identical to the dose recommended for intramuscular administration. The solution for intravenous use is prepared by adding the contents of a 500 mg vial to 100 or 200 ml of sterile diluent such as Normal Saline or 5% Dextrose in Water or any of the compatible solutions listed below.
The solution is administered to adults over 30 to 60 minutes period. The total daily dose should not exceed 15 mg/kg/day and may be divided into, either 2 to 3 equally divided doses at equally divided intervals.