Gastrointestinal disturbances include nausea, vomiting, diarrhea, abdominal pain and dyspepsia are the most frequent adverse effects. Pseudomembranous colitis has been reported rarely.
Headache, dizziness and restlessness are among the most commonest effects on the CNS. In addition to rash and pruritus, hypersensitivity type reactions affecting the skin have included, rarely, vasculitis, erythema multiforme, Stevens Johnson syndrome, and toxic epidermal necrolysis. Photosensitivity has occured and may be more frequent with some newer fluoroquinolones such as lomefloxacin and sparfloxacin. Anaphylaxis has been reported. As with other quinolone antibacterials, reversible arthralgia has sometimes occurred and joint erosions have been documented in immature animals. Tendon damage has been reported.
Other adverse effects reported with Ciprofloxacin include transient increases in serum creatinine or blood urea nitrogen and occasionally, acute renal failure secondary to interstitial nephritis; crystalluria; elevated liver enzyme values, jaundice and hepatitis; haematological disturbances including eosinophilia, leucopoenia, thrombocytopenia and very rarely, hemolytic anemia or agranulocytosis; myalgia; gynaecomastia, and cardiovascular effects including tachycardia.