Adult 250-750 mg bid. Gonorrhea 250 or 500 mg once daily. Meningococcal meningitis prophylaxis 500 mg once daily. Surgical infection prophylaxis 750 mg as a single dose given 60-90 min pre-op. Acute exacerbations of cystic fibrosis associated w/ P. aeruginosa infectionAdult & childn >5 yr 20 mg/kg bid. Max: 750 mg bid.
Epilepsy or history of CNS disorders. Discontinue use if tendon pain, inflammation or rupture occurs. Hepatic or renal impairment, G6PD deficiency, myasthenia gravis. Maintain adequate fluid intake. Avoid excessive alkalinity of the urine & exposure to strong sunlight & sunlamps. May impair ability to drive or operate machinery especially w/ alcohol use.
Elevated serum conc & prolonged elimination t1/2 of theophylline. Increased t1/2 & decreased clearance of caffeine. May interfere absorption w/ antacids containing Mg, Al or Ca. Altered serum levels of phenytoin. Enhanced effects of warfarin & its derivatives. Interfered w/ renal tubular secretion w/ probenecid.
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