Rarely, shock may occur, it should therefore be observed sufficiently. If any symptom occurs, the administration should be discontinued and appropriate therapy instituted.
Rarely, muco-cutaneous-ocular syndrome (Stevens-Johnson syndrome), photosensitivity may occur, it should therefore be observe sufficiently. If they occur the administration should be discontinued.
Rare cases of pharyngeal edema, facial edema, pruritus, flush, may occur. If they occur the administration should be discontinued.
Rarely, acute kidney failure, and occasionally, increased serum creatinine and BUN concentration may occur.
Rarely, jaundice, and occasionally, elevations in GOT, GPT, Al-P may occur, it should therefore observed sufficiently. If any symptom occurs, the administration should be discontinued and appropriate therapy instituted.
Occasionally, leukopenia, thrombocytopenia, eosinophilia, and rarely, decreased platelet count, oligochromemia, decreased hematocrit level may occur.
Rarely, severe colitis accompanied with hemafecia including pseudomembranous colitis, may occur. If abdominal pain, frequent diarrhea occurs, an appropriate therapy, such as discontinuation of the therapy, should be instituted. Occasionally, anorexia, diarrhea, gastric discomfort, vomiturition, vomiting, abdominal pain, abdominal distention, and rarely, stomatitis may also occur.
Central Nervous System:
Occasionally, headache, dizziness and rarely, lingual numbness, drowsiness, tremor, visual disorder may occur.
Myalgia, a sense of exhaustion, increased CPK, myocytosis of striated muscle accompanied with sudden ingravescence of renal function, which increases myoglobin in blood and urine may occur, it should therefore be cautioned.
Interstitial pneumonia, accompanied with flush, dyspnea, disorder of chest X, eosinophilia, may occur. If these symptoms occur, the administration should be discontinued and appropriate therapy, including adenocortical hormone therapy, instituted.
Rarely, arthralgia may occur.
Rare case of hypoglycemia by other new quinolone antibacterial has been reported (it occurs frequently in the elderly patients, especially, patients with renal impairment), it should therefore cautioned.
Seizure, somniopathy may occur.
In a foreign country, rare cases of tendon disorder, such as Achilles tendonitis, tendon rupture, have been reported, it should therefore observe sufficiently. If any symptom occurs, the administration should be discontinued and appropriate therapy instituted.
In animal studies (young dogs, young rats), dysarthrosis has been occurred.
In mass-dose administration (more than 750mg/time), crystalluria has been reported.