The risk of crystalluria is high in patients with alkaline urine.
Renal Impairment: Ciprofloxacin should be use with caution in patients with impaired renal function. Dose should be reduced when giving ciprofloxacin to patients with severe renal impairment. (See Dosage & Administration.)
Hepatic Impairment: Ciprofloxacin should be used with caution in patients with severe hepatic impairment where peak plasma concentration and serum t½ may be increased.
Effects on the Ability to Drive or Operate Machinery: Patients who drive and operate machines must not take ciprofloxacin with alcohol.
Use in the elderly: Dose of ciprofloxacin should be reduced in the elderly as increased bioavailability and reduced renal clearance were seen probably due to absorption or first-pass elimination.