Gastrointestinal disturbances including nausea, vomiting, diarrhea, abdominal pain and dyspepsia. Pseudomembranous colitis has been reported rarely. Headache, dizziness and restlessness are among the most common effect on the CNS. Others include tremor, drowsiness, insomnia, nightmares, and visual and other sensory disturbances and more rarely, hallucinations, psychotic reactions, depression and convulsions. Paresthesia and peripheral neuropathy have occurred occasionally.
In addition to rash and pruritus, hypersensitivity-type reactions affecting the skin have included, rarely, vasculitis, erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis. Photosensitivity has occurred.
Other adverse effects reported include transient increase in serum creatinine or blood urea nitrogen and, occasionally acute renal failure secondary to interstitial nephritis, crystalluria, elevated liver enzyme values, jaundice and hepatitis; hematological disturbances.
As with other antibacterials, superinfection with organisms not very susceptible to ciprofloxacin is possible.