Claricort has no clinically significant sedative properties at the daily recommended dose (10 mg).
Most commonly reported side effects include: Fatigue, headache, somnolence, nervousness, dry mouth, gastrointestinal disorders eg, nausea, gastritis and also allergic symptoms eg, rash.
During the marketing of loratadine, alopecia, anaphylaxis and abnormal hepatic function have been reported rarely.
Adverse reactions to betamethasone which have been the same as those reported for other corticosteroids, relate both to dose and to duration of therapy. Usually, these reactions can be reversed or minimized by a reduction in dosage; this is generally preferable to withdrawal of drug treatment.
Fluid and Electrolyte Disturbances:
Sodium retention, potassium loss, hypokalemic alkalosis; fluid retention; congestive heart failure in susceptible patients; hypertension.
Muscle weakness, corticosteroid myopathy, loss of muscle mass; aggravation of myasthenic symptoms in myasthenia gravis; osteoporosis; vertebral compression fractures; aseptic necrosis of femoral and humeral heads; pathologic fracture of long bones; tendon rupture.
Peptic ulcer with possible subsequent perforation and hemorrhage; pancreatitis, abdominal distention; ulcerative esophagitis.
Impaired wound healing, skin atrophy, thin fragile skin; petechiae and ecchymoses; facial erythema; increased sweating; suppressed reactions to skin tests; reactions eg, allergic dermatitis, urticaria, angioneurotic edema.
Convulsions; increased intracranial pressure with papilledema (pseudotumor cerebri) usually after treatment; vertigo; headache.
Menstrual irregularities; development of Cushingoid state; suppression of fetal intrauterine or childhood growth; secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery or illness; decreased carbohydrate tolerance, manifestations of latent diabetes mellitus, increased requirements of insulin or oral hypoglycemic agents in diabetics.
Posterior subcapsular cataracts; increased intraocular pressure, glaucoma; exophthalmos.
Negative nitrogen balance due to protein catabolism.
Euphoria, mood swings; severe depression to frank psychotic manifestations; personality changes; hyperirritability; insomnia.
Anaphylactoid or hypersensitivity and hypotensive or shock-like reactions.