Clarie DS 125/Clarie DS 250

Clarie DS 125/Clarie DS 250

clarithromycin

Manufacturer:

Ind-Swift

Distributor:

Ambica

Marketer:

Ambica
Concise Prescribing Info
Contents
Clarithromycin
Indications/Uses
Resp tract (including otitis media), skin & soft tissue infections. H. pylori eradication in treatment regimens for peptic ulcer. Clarie DS 125 Leprosy. Prophylaxis & treatment of opportunistic mycobacterial infections. Clarie DS 250 Mild to moderate infections (pharyngitis/tonsillitis; acute maxillary sinusitis; acute bacterial exacerbation of chronic bronchitis; community acquired pneumonia; uncomplicated skin & skin structure infections; disseminated mycobacterial infections).
Dosage/Direction for Use
Childn Recommended dose: 15 mg/kg daily 12 hrly for 10 days; Weighing 33 kg 250 mg 12 hrly, 25 kg 187.5 mg 12 hrly, 17 kg 125 mg 12 hrly, 9 kg 62.5 mg 12 hrly. Treatment of disseminated Mycobacterium avium complex (MAC) Adult 500 mg bid. Childn 7.5 mg/kg bid.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to clarithromycin, erythromycin or other macrolides. Concomitant use w/ cisapride, pimozide, astemizole or terfenadine.
Special Precautions
Severe renal impairment w/ or w/o coexisting hepatic impairment. Do not use in combination w/ ranitidine bismuth citrate for patients w/ history of acute porphyria & CrCl <25 mL/min. MAC patients <20 mth of age. Pregnancy.
Adverse Reactions
Diarrhea, nausea, abnormal taste, dyspepsia, abdominal pain, headache, allergic reaction, CNS effects.
Drug Interactions
Increased serum theophylline conc; plasma conc of carbamazepine & active acid metabolite of terfenadine; conc of HMG-CoA reductase inhibitors (eg, lovastatin & simvastatin; cisapride, pimozide, astemizole; zidovudine; cyclosporine, tacrolimus, hexobarbital, phenytoin, alfentanil, disopyramide, bromocriptine, valproate, rifabutin). Increased clarithromycin AUC & decreased 14-OH clarithromycin AUC in concomitant use w/ ritonavir. May potentiate effects of oral anticoagulants.
MIMS Class
ATC Classification
J01FA09 - clarithromycin ; Belongs to the class of macrolides. Used in the systemic treatment of infections.
Presentation/Packing
Form
Clarie DS 125 powd for oral susp 125 mg/5 mL
Packing/Price
50 mL x 1's
Form
Clarie DS 250 powd for oral susp 250 mg/5 mL
Packing/Price
50 mL x 1's
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