Clariget: Adults: Usual Recommended Dose: One 250-mg tab twice daily. In more severe infections, the dosage can be increased to 500 mg twice daily. Usual Duration of Therapy: 6-14 days. The suspension may be used as an alternative dosage form for those adults that prefer a liquid medicine.
The following text is a suggested guide for determining dosage: Pharyngitis/Tonsillitis: 250 mg every 12 hrs for 10 days.
Acute Maxillary Sinusitis: 500 mg every 12 hrs for 14 days.
Acute Exacerbation of Chronic Bronchitis due to S. pneumoniae and M. catarrhalis: 250 mg every 12 hrs for 7-14 days; H. influenzae: 500 mg every 12 hrs for 7-14 days.
Pneumonia due to S. pneumoniae and M. pneumoniae: 250 mg every 12 hrs for 7-14 days.
Uncomplicated Skin and Skin Structure Infections: 250 mg every 12 hrs for 7-14 days.
Children: Usual Recommended Dose: 7.5 mg/kg twice daily up to a maximum of 500 mg twice daily. Usual Duration of Treatment: 5-10 days depending on the pathogen involved and the severity of the condition.
The following text is the suggested Pediatric Dosage Guideline for determining dosage based on body weight*:
8-11 kg (1-2 years)**: 62.5 mg or 2.5 mL (½ tsp); 12-19 kg (3-6 years): 125 mg or 5 mL (1 tsp); 20-29 kg (7-9 years): 187.5 mg or 7.5 mL (1½ tsp); 30-40 kg (10-12 years): 250 mg or 10 mL (2 tsp). All doses to be given twice daily.
*Children <8 kg should be dosed on a per kg basis (~7.5 mg/kg twice daily).
Eradication of H. pylori Associated with Peptic Ulcer Disease: 500 mg twice daily given with another antibacterial and either a proton pump inhibitor or a histamine H2-receptor antagonist for 7-14 days.
Mycobacterial Infections: Recommended Dose: 7.5-15 mg/kg twice daily in children with disseminated or localized mycobacterial infections (M. avium, M. intracellulare, M. chelonae, M. fortuitum and M. kansasii).
Treatment of disseminated MAC infections in AIDS patients should be continued as long as clinical and microbiological benefit is demonstrated. Treatment of other mycobacterial infections should continue at the discretion of the physician. Clarithromycin should be used in conjunction with other antimycobacterial agents. Dosing recommendations for children are in the table. (See table.)
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Renal Impairment: Clariget may be administered without dosage adjustment in the presence of hepatic impairment if there is normal renal function. However, in the presence of severe renal impairment (CrCl <30 mL/min), with or without coexisting hepatic impairment, the dose should be halved or the dosing interval doubled.
In children with creatinine clearance <30 mL/min, the dosage of clarithromycin should be reduced by ½ ie, up to 250 mg once daily or 250 mg twice daily in more severe infections. Dosage should not be continued beyond 14 days in these patients.
Susp: Directions for Preparation: Fill previously boiled and cooled water up to the line mark on the bottle and shake vigorously. The reconstituted suspension can be used for up to 14 days when stored at the required conditions.
Clariget OD: Usual Recommended Dose: Adult: 500 mg once daily.
More severe infections: Dosage may be increased to 1000 mg once daily (2 x 500 mg).
Usual Duration of Therapy: 5-14 days, excluding treatment of community-acquired pneumonia and sinusitis which require 6-14 days of therapy.
Renal Impairment: Moderate Renal Function (CrCl 30-60 mL/min): 50% dosage reduction should be implemented resulting in a maximum dose of Clariget OD 1 tablet/day.
Administration: Clariget OD should be taken with food and should be swallowed whole and not chewed, broken or crushed.