Increased toxicity of rifabutin. Delirium may occur w/ fluoxetine. Metabolism inhibited w/ ritonavir. Decreased plasma conc & high incidence of skin rashes w/ efavirenz. Altered pharmacokinetic parameters w/ cimetidine. Increased conc w/ omeprazole. Enhanced activity w/ antimycobacterials (eg, ethambutol, INH, pyrazinamide & rifampicin). Increased serum conc of theophylline & digoxin. Increased plasma conc of carbamazepine & terfenadine. Increased mean steady-state Cmin
& AUC w/ fluconazole. Potentiate effects of oral anticoagulants. Increased toxicity of colchicines. Torsades de pointes may occur w/ quinidine or disopyramide. Acute toxicity w/ ergotamine or dihydroergotamine. CNS effects w/ triazolam, alprazolam & other benzodiazepines. Increased conc of lovastatin & simvastatin. Increase AUC of sildenafil. Cyclosporine, tacrolimus, alfentanil, disopyramide, quinidine, methylprednisolone, cilostazol, bromocriptine, hexobarbital, phenytoin & valproate.