Clobenate

Clobenate

clobetasol

Manufacturer:

Micro Labs

Distributor:

UNILAB, Inc

Marketer:

Westmont
Concise Prescribing Info
Contents
Clobetasol propionate
Indications/Uses
Relief & short-term treatment of inflammatory & pruritic manifestations of corticosteroid-responsive dermatoses including psoriasis (eg, moderate to severe plaque-type psoriasis), eczematous dermatitis, recalcitrant dermatoses, lichen planus, discoid lupus erythematosus, other skin conditions which do not respond satisfactorily to less potent steroids.
Dosage/Direction for Use
Adult Short-term use Apply on the entire affected area/s once daily or bid (preferably in the morning & evening). Max: 50 g/wk. Patient who frequently relapse (recalcitrant dermatoses) Intermittent dosing (1-2 times a wk w/o occlusion).
Contraindications
Hypersensitivity. Untreated cutaneous infections, rosacea, acne vulgaris, pruritus w/o inflammation, perioral dermatitis, perianal & genital pruritus, primary cutaneous viral infections (eg, herpes simplex, chickenpox). Childn <12 yr.
Special Precautions
Avoid contact w/ the eyes. Do not apply occlusive dressings (including bandages) to areas of application. May cause systemic manifestations of hypercortisolism & reversible HPA axis suppression & should be w/drawn gradually. Cushing's syndrome, hyperglycemia & unmasking of latent diabetes; local adverse reactions may occur. History of local hypersensitivity to other corticosteroids. Concomitant skin infections. Psoriasis & development of local or systemic toxicity. Renal & hepatic impairment. Pregnancy & lactation. Elderly ≥65 yr.
Adverse Reactions
Burning or stinging of the skin. Hypercorticism (prolonged use >14 days of large amount ≥2 g/day).
Drug Interactions
May increase total systemic corticosteroid exposure w/ other corticosteroid-containing products. Increased systemic exposure w/ CYP3A4 inhibitors (eg, ritonavir & itraconazole).
ATC Classification
D07AD01 - clobetasol ; Belongs to the class of very potent (group IV) corticosteroids. Used in the treatment of dermatological diseases.
Presentation/Packing
Form
Clobenate topical cream 500 mcg/g (0.05% w/w)
Packing/Price
15 g x 1's;5 g x 1's
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