The most common (5%) adverse effect with clobetasol proprionate is burning or stinging of the skin. As with other topical corticosteroids, prolonged use (i.e., >14 days) of large amounts (i.e., ≥2 g/day) of clobetasol or treatment of extensive areas can result in sufficient systemic absorption to produce the features of hypercorticism.
Less common adverse effects (<2% of patients) include: Immune System: Generalized rash, hypersensitivity.
Endocrine: HPA axis suppression, including Cushingoid features (e.g., moon face, central obesity), delayed weight gain/growth retardation in children, osteoporosis, glaucoma, hyperglycemia/glucosuria, cataract, hypertension, increased weight or obesity, decreased endogenous cortisol levels, alopecia, trichorrhexis.
Skin and Subcutaneous Tissue: Allergic contact dermatitis or dermatitis, cracking and fissuring of the skin, erythema, exacerbation of underlying symptoms, folliculitis, hypertrichosis, irritation, pigmentation changes, pruritus, pustular psoriasis, rash, skin atrophy, skin dryness, skin thinning, skin wrinkling, striae, telangiectasia, urticaria.
Others: Application site irritation/pain, dilatation of superficial blood vessels, numbness of the fingers, opportunistic infection, tenderness in the elbow.