Corticosteroids: Do not use other corticosteroid-containing products with clobetasol proprionate unless directed by a physician. Concomitant use may increase the total systemic corticosteroid exposure.
Drugs inhibiting cytochrome P3A4 (CYP3A4): These drugs (e.g., ritonavir and itraconazole) have been shown to inhibit the metabolism of corticosteroids leading to increased systemic exposure. Clinical relevance of this interaction depends on the dose and route of administration of the corticosteroids and the potency of the CYP3A4 inhibitor.
Tell the doctor if the patient is taking other medicines, including vitamins, supplements, and herbal medicines.