Patients who have lesions w/ a propensity to bleed (eg, ulcers). Reye's syndrome may develop in patients w/ chicken pox, flu or flu symptoms. Patients w/ nasal polyps or nasal allergies. Hepatic & renal impairment. Pregnancy (3rd trimester) & lactation. Childn. Clopidogrel: Thrombotic thrombocytopenic purpura. Concomitant use w/ other NSAIDs. Increased risk of bleeding from trauma, surgery, or other pathological conditions. Discontinue 7 days prior to surgery. Aspirin: Hypersensitivity to anti-inflammatory or antirheumatic drugs & other allergens. History of GI disorders. Salicylate intoxication (salicylism) in large doses &/or prolonged therapy.
May increase bleeding time of anticoagulants. Increased risk of GI ulceration w/ pyrazolone derivatives (phenylbutazone, oxyphenylbutazone & dipyrone). Clopidogrel: Increased occult GI blood loss w/ naproxen. May interfere w/ the metabolism of phenytoin, tamoxifen, tolbutamide, torsenamide & fluvastatin. Aspirin: May enhance effect of oral hypoglycemic. May decrease uricosuric effects of probenecid, sulfinpyrazone & phenylbutazone. May decrease Na excretion produced by spironolactone. Produce changes in thyroid function test. Increased risk of GI bleeding. Increased risk of GI ulceration & reduce serum salicylate level w/ corticosteroids. Decreased effectiveness w/ urinary alkalinizers & phenobarb. May increase levels of phenytoin.