View Co-Avox overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food: May be taken at the start of the meal to minimize potential GI intolerance.
Contraindications
History of hypersensitivity reactions (eg, anaphylaxis or Stevens-Johnson syndrome) to amoxicillin, clavulanate or to other β-lactam antibacterial drugs (eg, penicillin & cephalosporins). Cholestatic jaundice/hepatic dysfunction.
Discontinue if an allergic reaction occurs. Patients w/ renal impairment. Monitor hepatic function at regular intervals in patients w/ hepatic impairment. C. difficile associated diarrhea must be considered in all patients who present w/ diarrhea following antibacterial use. Erythematous rash may develop in patients w/ mononucleus during therapy. Possibility of superinfections w/ fungal or bacterial pathogens. Risk of development of drug-resistant bacteria. Labor & delivery. Pregnancy & lactation. Elderly & ped patients <12 wk.
Increased & prolonged blood conc w/ probenecid. Prolongation of prothrombin time w/ oral anticoagulants. Increased incidence of rashes w/ allopurinol. May reduce efficacy of oral estrogen/progesterone contraceptives. May result in false +ve reactions when testing for the presence of glucose in urine.
J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
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