Co-Avox

Co-Avox

amoxicillin + clavulanic acid

Manufacturer:

Lloyd

Distributor:

Pharma Dynamic
Concise Prescribing Info
Contents
Co-Amoxiclav (amoxicillin & clavulanic acid). Amoxicillin trihydrate 500 mg, clavulanate K 125 mg
Indications/Uses
Lower resp tract infections, acute bacterial otitis media, sinusitis, UTI, skin & tissue infections. Amoxicillin resistant β-lactamase producing strains. Recurrent tonsillitis, acute exacerbations of chronic bronchitis, bronchopneumonia, septic abortion, pelvic or puerperal sepsis & intra-abdominal sepsis, cellulitis, animal bites & severe dental abscess w/ spreading cellulitis.
Dosage/Direction for Use
1 tab every 12 hr. Severe infections & infections of resp tract One 500-mg tab every 8 hr.
Administration
May be taken with or without food: May be taken at the start of the meal to minimize potential GI intolerance.
Contraindications
History of hypersensitivity reactions (eg, anaphylaxis or Stevens-Johnson syndrome) to amoxicillin, clavulanate or to other β-lactam antibacterial drugs (eg, penicillin & cephalosporins). Cholestatic jaundice/hepatic dysfunction.
Special Precautions
Discontinue if an allergic reaction occurs. Patients w/ renal impairment. Monitor hepatic function at regular intervals in patients w/ hepatic impairment. C. difficile associated diarrhea must be considered in all patients who present w/ diarrhea following antibacterial use. Erythematous rash may develop in patients w/ mononucleus during therapy. Possibility of superinfections w/ fungal or bacterial pathogens. Risk of development of drug-resistant bacteria. Labor & delivery. Pregnancy & lactation. Elderly & ped patients <12 wk.
Adverse Reactions
Hepatitis & cholestatic jaundice. Clavulanic acid: Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, nausea, vomiting, diarrhea, rashes & antibiotic-associated colitis.
Drug Interactions
Increased & prolonged blood conc w/ probenecid. Prolongation of prothrombin time w/ oral anticoagulants. Increased incidence of rashes w/ allopurinol. May reduce efficacy of oral estrogen/progesterone contraceptives. May result in false +ve reactions when testing for the presence of glucose in urine.
MIMS Class
Penicillins
ATC Classification
J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Presentation/Packing
Form
Co-Avox FC tab
Packing/Price
30's (P1,395/box)
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