Since both 250- and 500-mg tablets of CO-AX contain the same amount of clavulanic acid (ie, 125 mg clavulanic acid as potassium salt), two 250-mg CO-AX tablets are not equivalent to one 500-mg CO-AX tablet; therefore, two 250-mg CO-AX tablets should not be substituted for one 500-mg CO-AX tablet.
Adults: Usual Dose: 250-500 mg every 8 hrs or 500-875 mg every 12 hrs.
Severe Infections and Infections of the Respiratory Tract: 500 mg every 8 hrs or 875 mg every 12 hrs.
Renal Impairment: Patients with impaired renal function do not generally require a reduction in dose unless the impairment is severe.
Patient with Glomerular Filtration Rate (<30 mL/min): 1 g; 10-30 mL/min: 500 or 250 mg every 12 hrs depending on the severity of the infection; <10 mL/min: 500 or 250 mg every 24 hrs depending on the severity of the infection.
Hemodialysis Patient: 500 or 250 mg every 24 hrs depending on severity of the infection. They should receive an additional dose both during and at the end of dialysis.
Hepatic Impairment: Hepatically impaired patients should be dosed with caution and hepatic function must be monitored at regular intervals (see Warnings).
Children: Pediatric patients weighing ≥40 kg should be dosed according to the adult recommendations.
Administration: CO-AX may be taken without regard to meals; however, absorption of clavulanate potassium is enhanced when CO-AX tablet is administered at the start of a meal. To minimize the potential for GI intolerance, CO-AX tablet should be taken at the start of a meal.