Co-Normoten/Co-Normoten DS

Co-Normoten/Co-Normoten DS

losartan + hydrochlorothiazide




Concise Prescribing Info
Co-Normoten Losartan K 50 mg, hydrochlorothiazide 12.5 mg. Co-Normoten DS Losartan K 100 mg, hydrochlorothiazide 25 mg
Dosage/Direction for Use
Co-Normoten 50 mg/12.5 mg 1 tab daily. May increase to 2 tab daily if BP remains uncontrolled after 3 wk of therapy. Co-Normoten DS 100 mg/25 mg 1 tab daily. Max: 1 tab.
May be taken with or without food.
Hypersensitivity to losartan K, hydrochlorothiazide or other sulphonamide-derived drugs; impaired liver function, patients whose renal function may depend on the activity of the renin-angiotensin aldosterone system (eg, severe CHF), unilateral or bilateral renal artery stenosis; increase in serum creatinine or BUN; intravascular vol depleted (eg, those treated w/ diuretics), SLE. Lactation. Elderly.
Special Precautions
Hepatic impairment or severe renal impairment, bilateral renal artery stenosis of the artery to a solitary kidney. Periodic determination of serum electrolyte at appropriate intervals in patients receiving diuretics. May cause intermittent & slight elevation of serum Ca, marked hypercalcemia may be evidence of hidden hyperparathyroidism. Patients w/ or w/o history of allergy or bronchial asthma. Exacerbation or activation of lupus erythematosus. Risk of fetal or neonatal jaundice & thrombocytopenia. Pregnancy. Childn.
Adverse Reactions
Abdominal pain, edema, swelling, palpitation, back pain, dizziness, cough, sinusitis, upper resp tract infection, rash.
Drug Interactions
Alcohol, barbiturates or narcotics, antidiabetic drugs, other antihypertensive drugs, cholestyramine & colestipol resins, corticosteroids, pressor amines (eg, norepinephrine), skeletal muscle relaxants, lithium, NSAIDs. Losartan: Increased AUC w/ cimetidine.
ATC Classification
C09DA01 - losartan and diuretics ; Belongs to the class of angiotensin II receptor blockers (ARBs) in combination with diuretics. Used in the treatment of cardiovascular disease.
Co-Normoten FC tab
100's (P2,060/pack)
Co-Normoten DS FC tab
30's (P885/pack)
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