Diarrhea, pseudo membrane colitis, emesis, indigestion, nausea, stomatitis have been reported. Candidiasis, antibiotic-associated colitis (including pseudo membranous colitis and hemorrhagic colitis) has been reported rarely. The overall incidence of side effects, and in particular nausea, increased with the higher recommended dose.
If gastrointestinal reactions are evident, they made be reduced by taking Co-Amoxiclav (COBIOMAX) at the start of the meal. As with other antibiotics, the incidence of gastrointestinal side effects may be raised in children under two years. In clinical trials, however, only 4% of children under two years were withdrawn from treatment.
Moderate rise in AST (SGOT) and/ or ALT (SGPT) has been noted in patients treated with ampicillin class antibiotics but the significance of these findings is unknown. Hepatic dysfunction, including increases in serum transaminases (AST and/or ALT), serum bilirubin and/or alkaline phosphate, has been infrequently reported with amoxicillin; potassium Clavulanate. It has been reported more commonly in the elderly, in males, or in patients on prolonged treatment. The histologic findings on liver biopsy have consisted of predominantly cholestatic, hepatocellular, or mixed cholestatic hepatocellular changes. The onset of signs/ symptoms of hepatic dysfunction may occur during or several weeks after therapy have been discontinued. The hepatic dysfunction, which may be severe, is usually reversible. On rare occasions, deaths have been reported.
Skin rashes (urticarial and erythematous rashes) sometimes occur. Rarely erythema multiforme, Steven-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, acute generalized exanthematous pustulosis, angioedema have been reported rarely. Treatment should be discontinued if one of these disorders occurs. In common with other β-lactamase antibiotics angioedema, anaphylaxis serum sickness-like syndrome and hypersensitivity vasculitis have been reported.
As antibiotic other β-lactam, reversible leucopenia (including if hypoeosinophilia and granulocytopenia), reversible thrombocytopenia and hemolytic anemia, thrombocytopenic purpura, osinophilia, leucosis, agranulocytosis have been reported.
Central Nervous System:
Side effects, such as reversible hypersensitivity, dizziness, headache and convulsions have been reported rarely. Convulsion may occur in patients with impaired renal functions or those receiving high dose.
Interstitial nephritis and hematuria have been reported rarely.
Sometimes, dental discoloration has been reported rarely in children.