Combetzar

Combetzar

losartan + hydrochlorothiazide

Manufacturer:

Macheal Lab

Distributor:

Better Option

Marketer:

Suhitas
Concise Prescribing Info
Contents
Losartan K 50 mg, hydrochlorothiazide 12.5 mg
Indications/Uses
HTN not adequately controlled on monotherapy.
Dosage/Direction for Use
1 tab once daily, may be increased to 2 tab once daily after several wk. Elderly >75 yr, moderate to severe renal impairment or IM vol depletion ½ tab once daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to other sulfonamide derivatives. Anuria. Pregnancy (2nd & 3rd trimester) & lactation.
Special Precautions
Renal impairment. Do not use w/ hepatic impairment. Pregnancy (1st trimester). Childn.
Adverse Reactions
Palpitations, orthostatic effects, angina pectoris, arrhythmias (eg, atrial fibrillation, sinus bradycardia, tachycardia, ventricular tachycardia/fibrillation), CVA, hypotension, MI, 2nd-degree AV-block; dizziness, syncope, anxiety, ataxia, confusion, depression, dream abnormality, hyperesthesia, insomnia, decreased libido, memory impairment, migraine, nervousness, panic disorder, paresthesia, peripheral neuropathy, sleep disorder, somnolence, tremor, vertigo; rash, alopecia, dermatitis, dry skin, ecchymosis, erythema, flushing, photosensitivity, pruritus, sweating, urticaria; abdominal pain, anorexia, constipation, dental pain, dry mouth, dyspepsia, flatulence, gastritis, vomiting; impotence, nocturia, urinary frequency, UTI; anemia; edema, gout; upper resp tract infection, dyspnea, epistaxis, resp congestion. Hydrochlorothiazide: Orthostatic hypotension; restlessness; photosensitivity, urticaria, necrotizing angitis (vacuitis & cutaneous vasculitis), erythema multiforme (eg, Stevens-Johnson syndrome), exfoliative dermatitis (eg, toxic epidermal necrolysis), purpura; sinusitis, cough, nasal congestion, angioedema, pharyngeal discomfort, rhinitis, blurred vision, xanthopsia; pancreatitis, sialadenitis, cramping, gastric irritation; glucosuria, renal failure, renal dysfunction, interstitial nephritis; aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia; jaundice (interhepatic cholestatic jaundice); hyperglycemia, hyperuricemia; resp distress (eg, pneumonitis, pulmonary edema).
Drug Interactions
Losartan: Elevated plasma levels w/ fluconazole & lithium. Reduced plasma levels w/ rifamycins (eg, rifampin). May increase serum K w/ K-sparing diuretics (eg, spironolactone), K supplements, salt substitutes containing K. Hydrochlorothiazide: May increase risk of orthostatic hypotension w/ alcohol, barbiturates, narcotics. Antidiabetic agents. May potentiate actions of other antihypertensives. Absorption may be impaired by cholestyramine, colestipol resins. Increased risk of electrolyte depletion (eg, hypokalemia) w/ ACTH, corticosteroids. May decrease response to pressor amines (eg, norepinephrine). Increased responsiveness to nondepolarizing muscle relaxants (eg, tubocurarine). May elevate lithium plasma levels & increase the risk of lithium toxicity. Reduced antihypertensive, diuretic & natriuretic effects w/ NSAIDs.
ATC Classification
C09DA01 - losartan and diuretics ; Belongs to the class of angiotensin II receptor blockers (ARBs) in combination with diuretics. Used in the treatment of cardiovascular disease.
Presentation/Packing
Form
Combetzar FC tab
Packing/Price
30's;50's
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