At usual dosages, celecoxib is generally well tolerated. Adverse effects are usually mild and mainly involve the GI tract.
Cardiovascular: peripheral edema, angina pectoris, chest pain, coronary artery disorder, myocardial infarction, palpitation, tachycardia, aggravated hypertension, syncope, congestive heart failure, ventricular fibrillation, pulmonary embolism, cerebrovascular accident, peripheral gangrene, thrombophlebitis, deep-vein thrombosis, vasculitis.
Gastrointestinal: dyspepsia, diarrhea, constipation, abdominal pain, nausea, vomiting, flatulence, anorexia, diverticulitis, dry mouth, dysphagia, eructation, esophagitis, gastritis, gastroenteritis, gastroesophageal reflux, hemorrhoids, hiatal hernia, increased appetite, melena, stomatitis, taste perversion, tenesmus, tooth disorder, dry socket, intestinal obstruction, intestinal perforation, GI bleeding, colitis with bleeding, esophageal perforation, pancreatitis, cholelithiasis, ileus, intestinal anastomotic ulceration.
Nervous System: headache, migraine, dizziness, insomnia, somnolence, anxiety, asthenia, depression, hypertonia, hypoesthesia, nervousness, neuralgia, neuropathy, paresthesia, vertigo, aseptic meningitis, ataxia, ageusia, anosmia, fatal intracranial hemorrhage, suicide.
Respiratory: upper respiratory tract infection, sinusitis, pharyngitis, rhinitis, bronchitis, bronchospasm (including aggravated bronchospasm), coughing, dyspnea, laryngitis, pneumonia, nasopharyngitis.
Dermatologic and Sensitivity Reactions: rash, alopecia, dermatitis, dry skin, erythematous rash, maculopapular rash, nail disorder, photosensitivity reaction, pruritus, skin disorder, increased sweating, urticaria.
Allergic Reactions: aggravated allergy, bronchospasm, generalized or facial edema, angioedema, anaphylactoid reactions, erythema multiforme, exfoliative dermatitis, Sweet's syndrome, Stevens-Johnson Syndrome, toxic epidermal necrolysis.
Hematologic: anemia, ecchymosis, epistaxis, thrombocythemia, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, thrombocytopenia.
Renal and Genitourinary: albuminuria, cystitis, dysuria, hematuria, frequent micturition, renal calculus, urinary incontinence, urinary tract infection, dysmenorrhea, genital moniliasis, menstrual disorder, vaginal hemorrhage, vaginitis, prostatic disorder, acute renal failure, interstitial nephritis, renal papillary necrosis, renal injury.
Hepatic: Borderline elevations in serum ALT (SGPT) or AST (SGOT), jaundice, hepatitis, fatal fulminant hepatitis, liver necrosis, liver failure.
Musculoskeletal: back pain, arthralgia, arthrosis, bone disorder, leg cramps, myalgia, neck stiffness, synovitis, tendinitis, accidental fracture.
Special Senses: blurred vision, cataract, conjunctivitis, ocular pain, glaucoma, deafness, ear abnormality, earache, otitis media, tinnitus.
Metabolic: increases in: blood urea nitrogen (BUN), creatinine phosphokinase (CPK), nonprotein nitrogen (NPN), creatinine, alkaline phosphatase; diabetes mellitus, hyperglycemia, hypoglycemia, hypercholesterolemia, hypokalemia, hyponatremia, weight gain.
General: hot flushes, influenza-like symptoms, accidental injury, cysts, fatigue, fever, flu-like symptoms, soft tissue infection, bacterial infections, fungal infections (including moniliasis), viral infections (including herpes simplex or herpes zoster), pain and peripheral pain, sepsis, sudden death.