Hypersensitivity to the active substance or to any of the excipients.
The concomitant use of duloxetine with non-selective irreversible monoamine oxidase inhibitors (MAOIs) is contraindicated (see Interactions for details).
Liver disease resulting in hepatic impairment.
Duloxetine should not be used in combination with fluvoxamine, ciprofloxacin, or enoxacine (i.e. potent CYP1A2 inhibitors) since the combination results in elevated plasma concentrations of duloxetine.
Severe renal impairment (creatinine clearance less than 30 mL/min).