Cymbalta

Cymbalta Overdosage

duloxetine

Manufacturer:

Eli Lilly

Distributor:

Zuellig
Full Prescribing Info
Overdosage
In cases of acute ingestions up to 3000 mg, alone or in combination with other drugs, were reported with none being fatal. However, in post marketing experience, fatal outcomes have been reported for acute overdoses, primarily with mixed overdoses, but also with duloxetine only, at doses as low as approximately 1000 mg. Signs and symptoms of overdose (duloxetine alone or with mixed drugs) included somnolence, coma, serotonin syndrome, seizures, vomiting and tachycardia seizures.
In animal studies, the major signs of overdose toxicity are related to the central nervous and gastrointestinal systems. These include central nervous system effects such as tremors, clonic convulsions, ataxia, emesis, and decreased appetite.
No specific antidote is known, but if serotonin syndrome ensues, specific treatment (such as with cyproheptadine and/or temperature control) may be considered. An airway should be established. Monitoring of cardiac and vital signs is recommended, along with appropriate symptomatic and supportive measures. Gastric lavage may be indicated if performed soon after ingestion or in symptomatic patients. Activated charcoal may be useful in limiting absorption. Duloxetine has a large volume of distribution and forced diuresis, hemoperfusion, and exchange perfusion are unlikely to be beneficial.
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