Use with caution in patients with severe hepatic disease since these patients metabolize metronidazole slowly, with resultant accumulation of metronidazole and its metabolites in the plasma.
Alcoholic beverages should be avoided during metronidazole therapy and for at least 3 days afterward.
Patients with history of blood dyscrasias should use metronidazole with caution. Total and differential leukocyte counts should be performed before and after treatment especially when repeated courses of the drug are necessary.
Patients receiving corticosteroids and patients predisposed to edema should use metronidazole with caution.
Candida overgrowth in the gastrointestinal or genital tract may occur during metronidazole therapy and may require treatment with an agent with activity against Candida.