Concise Prescribing Info
Medroxyprogesterone acetate
Contraception & treatment of menorrhagia, secondary amenorrhea & mild to moderate endometriosis.
Dosage/Direction for Use
IM Contraception & menorrhagia 150 mg/3 mL w/in the 1st 5 days of cycle or w/in 1st 5 days after giving birth (delay until 6 wk after birth if lactating). Secondary amenorrhea 5-10 mg daily for 5-10 days until 2 days before onset of menstruation. Mild to moderate endometriosis 50 mg wkly or 100 mg every 2 wk for at least 6 mth.
Undiagnosed vag bleeding, history or current high risk of arterial disease, hormone-dependent neoplasms, hepatic impairment, porphyria, after recent evacuation of hydatidiform mole. Pregnancy.
Special Precautions
Cardiac or renal impairment, epilepsy, asthma, past ectopic pregnancy, history of depression, DM, HTN, migraine, thromboembolism, other conditions aggravated by fluid retention. Breastfeeding women.
Adverse Reactions
GI disturbances, appetite or wt changes, fluid retention, edema, acne, chloasma (melasma), allergic skin rashes, urticaria, mental depression, breast changes including discomfort or gynecomastia (occasionally), changes in libido, hair loss, hirsutism, fatigue, drowsiness, insomnia, fever, headache, premenstrual syndrome-like symptoms, altered menstrual cycle or irregular menstrual bleeding, inj-site reactions; altered serum lipid profile.
Drug Interactions
Markedly reduced plasma conc w/ aminoglutethimide. May influence diabetic control. May inhibit ciclosporin metabolism leading to increased plasma-ciclosporin conc & risk of toxicity. Antibacterials that induce liver enzyme production effect.
MIMS Class
Depot Contraceptives / Oestrogens, Progesterones & Related Synthetic Drugs
ATC Classification
G03AC06 - medroxyprogesterone ; Belongs to the class of progestogens. Used as systemic contraceptives.
Depotrust depot inj 50 mg/mL
3 mL x 1's (P123/syringe)
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