Skin and subcutaneous tissue: erythema, burning sensation of the skin, itching, acne, contact dermatitis, skin irritation, rash, pustular rash at the application site, urticaria, xerosis, skin flaking enchancement, sense of discomfort, hypersensitivity. Appendages of skin: folliculitis, hair restructuring, excessive hair dryness or oiliness, hair loss (baldness), change in hair color (generally in patients with chemically damaged or gray hair), nail discoloration. There are known cases of straightening of naturally curly hair. Nervous system and sense organs: eye irritation, eyelid edema, excessive tearing, taste perversion (dysgeusia), paresthesia, hypersensitivity. Immune system: hypersensitivity reactions, including anaphylactoid reactions.