Pharmacotherapeutic group: Imidazole and triazole derivatives. ATC Code: D01AC08.
Pharmacology: Pharmacodynamics: Ketoconazole is a synthetic imidazole dioxolane antimycotic active against yeasts, including Malassezia, and dermatophytes. Its broad spectrum of activity is already well known.
Ketoconazole also has a direct anti-inflammatory action independent from its antifungal activity which may contribute to symptom relief in dandruff and seborrhoeic dermatitis.
Pharmacokinetics: Plasma concentrations of ketoconazole were not detectable after topical administration of Dermazole shampoo on the scalp. Plasma levels were detected after topical administration of Dermazole shampoo on the whole body.