Dermovate Dosage/Direction for Use





Full Prescribing Info
Dosage/Direction for Use
Cream: Creams are especially appropriate for moist or weeping surfaces.
Ointment: Ointments are especially appropriate for dry, lichenified or scaly lesions.
Adults, Elderly and Children >1 year: Apply thinly and gently rub in using only an enough amount to cover the entire affected area once or twice daily for up to 4 weeks until improvement occurs, then reduce the frequency of application or change the treatment to a less potent preparation. Allow adequate time for absorption after each application before applying an emollient.
Repeated short courses of Dermovate may be used to control exacerbations.
In more resistant lesions, especially where there is hyperkeratosis, the effect of Dermovate can be enhanced, if necessary, by occluding the treatment area with polyethene film.
Overnight occlusion only is usually adequate to bring about a satisfactory response. Thereafter, improvement can usually be maintained by application without occlusion.
If the condition worsens or does not improve within 2-4 weeks, treatment and diagnosis should be re-evaluated.
Treatment should not be continued for >4 weeks. If continuous treatment is necessary, a less potent preparation should be used.
The maximum weekly dose should not exceed 50 g/week.
Atopic Dermatitis (Eczema): Therapy with Dermovate should be gradually discontinued once control is achieved and an emollient continued as maintenance therapy.
Rebound of preexisting dermatoses can occur with abrupt discontinuation of Dermovate.
Recalcitrant Dermatoses: Patients Who Frequently Relapse: Once an acute episode has been treated effectively with a continuous course of topical corticosteroid, intermittent dosing (once daily, twice weekly, without occlusion) may be considered. This has been shown to be helpful in reducing the frequency of relapse.
Application should be continued to all previously affected sites or to known sites of potential relapse. This regimen should be combined with routine daily use of emollients. The condition and the benefits and risks of continued treatment must be re-evaluated on a regular basis.
Children: Clobetasol propionate is contraindicated in children under one year of age. Children are more likely to develop local and systemic side effects of topical corticosteroids and in general, require shorter courses and less potent agents than adults.
Care should be taken when using Dermovate to ensure the amount applied is the minimum that provides therapeutic benefit.
Elderly: Clinical studies have not identified differences in responses between the elderly and younger patients. The greater frequency of decreased hepatic or renal function in the elderly may delay elimination if systemic absorption occurs. Therefore, the minimum quantity should be used for the shortest duration to achieve the desired clinical benefit.
Renal/Hepatic Impairment: In case of systemic absorption (when application is over a large surface area for a prolonged period), metabolism and elimination may be delayed, therefore increasing the risk of systemic toxicity. Therefore, the minimum quantity should be used for the shortest duration to achieve the desired clinical benefit.
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