Generic Medicine Info
Indications and Dosage
Allergic conditions
Adult: 5 mg once daily.
Child: 6-11 mth 1 mg; 1-5 yr 1.25 mg; 6-11 yr 2.5 mg. Doses to be taken once daily.
Renal Impairment
Initially, 5 mg every other day.
Hepatic Impairment
Initially, 5 mg every other day.
May be taken with or without food.
Special Precautions
Hepatic and renal impairment. Pregnancy and lactation.
Adverse Reactions
Pharyngitis, dry mouth, myalgia, fatigue, somnolence, headache, dizziness, insomnia, dysmenorrhoea, nausea, dyspepsia, diarrhoea, vomiting, anorexia, increased appetite, fever, UTI, varicella, upper resp tract infection, coughing, epistaxis, parasitic infection, bronchitis, otitis media, rhinorrhoea, emotional lability, irritability, maculopapular rash, erythema.
Drug Interactions
Potential increase in plasma concentrations w/ drugs affecting hepatic microsomal enzymes (e.g. azithromycin, cimetidine, erythromycin, fluoxetine, ketoconazole).
Food Interaction
May increase CNS depression w/ alcohol.
Description: Desloratadine is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils.
Onset: W/in 1 hr.
Duration: 24 hr.
Absorption: Time to peak plasma concentration: Approx 3 hr.
Distribution: Distributed into breast milk. Plasma protein binding: Approx 82-87%.
Metabolism: Extensively metabolised to 3-hydroxydesloratadine (active metabolite), which subsequently undergoes glucuronidation.
Excretion: Via urine and faeces as metabolites (approx 87%). Elimination half-life: 27 hr.
Store between 15-30°C.
MIMS Class
Antihistamines & Antiallergics
Anon. Desloratadine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 12/03/2014.

Buckingham R (ed). Desloratadine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. . Accessed 12/03/2014.

Clarinex (Merck Sharp & Dohme Corp.). DailyMed. Source: U.S. National Library of Medicine.

McEvoy GK, Snow EK, Miller J et al (eds). Desloratadine. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). Accessed 12/03/2014.

Disclaimer: This information is independently developed by MIMS based on Desloratadine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by
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