For Systemic Therapy: Gastric and duodenal ulcers, systemic fungal infections, certain viral infections e.g. varicella and herpes genitalia infections, glaucoma, hypersensitivity to glucocorticoids, sulfites or benzyl alcohol. In general, no contraindications apply in conditions where the use of glucocorticoids may be life-saving.
For Local Therapy: Infection of the affected site e.g. septic arthritis resulting from gonorrhea or tuberculosis, bacterecemia and systemic fungal infections, instability of joint and hypersensitivity to glucocorticoids.