Pharmacology: Pharmacodynamics: Dexamethasone is a synthetic glucocorticoid with seven (7) times the anti-inflammatory potency of prednisolone and thirty (30) times that of the natural
glucocorticoid, hydrocortisone. Like other glucocorticoids, dexamethasone also has antiallergic, antitoxic, antishock, antipyretic and immunosuppressive properties. It has virtually no water and salt-retaining properties and is, therefore particularly suitable for use in patients with cardiac failure or hypertension.
After administration, Dexamethasone sodium phosphate is rapidly hydrolyzed to dexamethasone. Because of the long biological half-life (36-54 hrs) is especially suitable in conditions where continuous glucocorticoid action is desired. Dexamethasone has plasma half-life of about 190 mins.