Dextein Overdosage



Temmler Pharma GmbH


Oxford Distributions


Glorious Dexa
Full Prescribing Info
With oral administration forms of acetylcysteine no cases of toxic overdose were observed so far. Volunteers were treated for 3 months with a daily dose of 11.6 g, without that severe side effects were observed. Oral doses of up to 500 mg acetylcysteine/kg body weight were tolerated without toxic symptoms.
Symptoms of Intoxication: Overdosage may lead to gastrointestinal symptoms like nausea, vomiting and diarrhea. In infants there is the danger of hypersecretion.
Therapy of Intoxication: Symptomatic treatment if necessary.
From the I.V. acetylcysteine treatment in case of paracetamol intoxication in humans there is experience with daily maximum doses up to 30 g of acetylcysteine. The I.V. application of highly concentrated acetylcysteine especially in case of fast application has lead to partly irreversible "anaphylactoid" reactions.
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