Dianorm

Dianorm

gliclazide

Manufacturer:

Merck

Distributor:

Zuellig
Concise Prescribing Info
Contents
Gliclazide
Indications/Uses
DM of the maturity onset type which cannot be controlled by diet alone.
Dosage/Direction for Use
Total daily dose: 40-320 mg orally. Adjusted to 40-80 mg daily & increase until adequate control is achieved. Max single dose: 160 mg. When higher doses are required, 80 mg tab should be taken bid according to the main meals of the day.
Administration
Should be taken with food.
Contraindications
Hypersensitivity. Diabetes complicated by acidosis, ketosis or coma. Juvenile onset diabetes & unstable or brittle diabetes. Severe renal & liver disease. Lactation.
Special Precautions
Acute complications eg, severe trauma, fever, infection or surgery. Hypoglycemia. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Patients w/ G6PD deficiency. Monitor patient regularly to ensure optimal control of diabetic state & adjust dosage if necessary. Particular care must be taken during the initial period of stabilization. Renal & hepatic insufficiency. Pregnancy.
Adverse Reactions
Hypoglycemia & GI disturbances including abdominal pain, nausea, vomiting, dyspepsia, diarrhea & constipation.
Drug Interactions
May adversely affect blood sugar control w/ thiazide diuretics, barbiturates, glucocorticoids & estrogens. Increased risk of hypoglycemia w/ insulin, biguanides, sulphonamides, oxyphenbutazone, phenylbutazone, clofibrate, salicylates, coumarin derivatives, chloramphenicol, MAOIs, β-blockers, cimetidine, ethanol, miconazole (systemic route, oromucosal gel), phenylbutazone (systemic route), alcohol. Potentiation of blood glucose lowering effect w/ other antidiabetic agents (insulins, acarbose, metformin, thiazolidinediones, dipeptidyl peptidase-4 inhibitors, GLP-1 receptor agonists), β-blockers, fluconazole, ACE inhibitors (captopril, enalapril), H2 antagonists, MAOIs, sulphonamides, clarithromycin & NSAIDs. Increased risk of hyperglycemia w/ danazol, chlorpromazine (neuroleptic agent), glucocorticoids (systemic & local route); & ritodrine, salbutamol, terbutaline (IV). Potentiation of anticoagulation during concurrent treatment of warfarin.
MIMS Class
ATC Classification
A10BB09 - gliclazide ; Belongs to the class of sulfonylureas. Used in the treatment of diabetes.
Presentation/Packing
Form
Dianorm tab 80 mg
Packing/Price
100's
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