Diapiptaz 4.5

Diapiptaz 4.5

piperacillin + tazobactam




Zyre Pharma


Concise Prescribing Info
Piperacillin Na 4 g, tazobactam Na 500 mg
Multidrug resistant gm -ve infections due to organism proven or suspected to be susceptible to piperacillin-tazobactam except CNS infections; & for polymicrobial infections (eg, mixed aerobic & anaerobic infections) except CNS infections in which other agents have insufficient activity or are contraindicated due to toxic potential.
Dosage/Direction for Use
IV infusion over 30 min. Adult 3.375 g every 6 hr. Nosocomial pneumonia 16 g piperacillin + 2 g tazobactam. Community-acquired pneumonia, intra-abdominal infections (appendicitis &/or peritonitis), uncomplicated & complicated skin problems Childn >40 kg 4.5 mg piperacillin + 4.5 mg tazobactam every 6 hr, up to 40 kg or >9 mth 100 mg piperacillin + 4.5 mg tazobactam + aminoglycoside every 6 hr, 2 mth & 9 mth 80 mg piperacillin + 10 mg tazobactam per kg every 8 hr.
Special Precautions
Cystic fibrosis, bowel inflammation, bleeding problems, CHF, history of severe diarrhea or bowel problems w/ antibiotics & on a salt-restricted diet or low blood K levels. Concomitant use w/ prescription/non-prescription medicine, herbal prep or dietary supplement, allergies to medicines, food or other substances. Pregnancy & lactation.
Adverse Reactions
Agitation, constipation, diarrhea, dizziness, headache, indigestion, nausea, pain, swelling or redness at the inj site, sleeplessness & vomiting.
Drug Interactions
Aminoglycosides, OCs, anticoagulants, heparin, methotrexate, non-depolarizing muscle relaxants, probenecid & tetracyclines.
MIMS Class
ATC Classification
J01CR05 - piperacillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Diapiptaz 4.5 powd for inj
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