Piperacillin + Tazobactam should be administered by intravenous infusion over 30 minutes or as prescribed by the physician.
The usual total daily dose of Piperacillin-Tazobactam is 3.375g every six hours totalling 13.5g (12.0g Piperacillin + 1.5g Tazobactam).
Initial presumptive treatment of patients with nosocomial pneumonia should start with 16.0g Piperacillin + 2.0g Tazobactam).
Treatment with aminoglycoside should be continued in patients from whom Pseudomonas aeruginosa
is isolated. If Pseudomonas aeruginosa
is not isolated, the aminoglycoside may be discontinued at the direction of the treating physician.
Piperacillin + Tazobactam can be administered in pediatric patients from 2 months of age. The dosage and indications in pediatric patients with normal renal function are as follows: (See Table.)
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Directions for Reconstitutions:
Dissolve the contents of the vial in 20 mL Sterile Water for Injection. The reconstituted solution should be used immediately after preparation and discard the unused remaining portion.