Diapiptaz 4.5

Diapiptaz 4.5

piperacillin + tazobactam




Zyre Pharma


Full Prescribing Info
Piperacillin sodium, tazobactam sodium.
Each vial contains: Piperacillin Sodium USP Eq. to Piperacillin 4 g, Tazobactam Sodium Eq. to Tazobactam 500 mg.
For the treatment of documented multidrug resistant Gram-negative infections due to organism proven or suspected to be susceptible to piperacillin-tazobactam except CNS infections; and for polymicrobial infections (e.g. mixed aerobic and anaerobic infections) excepts CNS infections in which other agents have insufficient activity or are contraindicated due to toxic potential.
Dosage/Direction for Use
Piperacillin + Tazobactam should be administered by intravenous infusion over 30 minutes or as prescribed by the physician.
Adults: The usual total daily dose of Piperacillin-Tazobactam is 3.375g every six hours totalling 13.5g (12.0g Piperacillin + 1.5g Tazobactam).
Initial presumptive treatment of patients with nosocomial pneumonia should start with 16.0g Piperacillin + 2.0g Tazobactam).
Treatment with aminoglycoside should be continued in patients from whom Pseudomonas aeruginosa is isolated. If Pseudomonas aeruginosa is not isolated, the aminoglycoside may be discontinued at the direction of the treating physician.
Pediatrics: Piperacillin + Tazobactam can be administered in pediatric patients from 2 months of age. The dosage and indications in pediatric patients with normal renal function are as follows: (See Table.)

Click on icon to see table/diagram/image

Directions for Reconstitutions: Dissolve the contents of the vial in 20 mL Sterile Water for Injection. The reconstituted solution should be used immediately after preparation and discard the unused remaining portion.
Special Precautions
Pregnancy, lactation, taking any prescription or non-prescription medicine, herbal preparation, or dietary supplement, allergies to medicines, food or other substances, cystic fibrosis, bowel inflammation, bleeding problems, congestive heart failure, kidney problems, history of severe diarrhea or bowel problems with antibiotics and on a salt-restricted diet or low blood potassium levels.
Adverse Reactions
Agitation, constipation, diarrhea, dizziness, headache, indigestion, nausea, pain, swelling or redness at the injection site, sleeplessness and vomiting.
Drug Interactions
Aminoglycosides, oral contraceptives, anticoagulants, heparin, methotrexate, non-depolarizing muscle relaxants, probenecid and tetracyclines.
Store at temperatures not exceeding 30°C.
MIMS Class
ATC Classification
J01CR05 - piperacillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Powd for inj (vial) 1's.
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