Avoid concomitant use w/ NSAIDs including COX-2 selective inhibitors. Bronchial asthma; renal function & cardiac impairment, liver dysfunction, those taking diuretics; mild to moderate renal impairment. Discontinue if abnormal liver function tests persist or worsen; mild to moderate hepatic function impairment; prodromal symptoms may occur; hepatic porphyria; history of HTN &/or mild to moderate CHF; CHF (NYHA-I) & patients w/ significant risk factors for CV events (eg, HTN, hyperlipidemia, DM, smoking); history of cerebrovascular bleeding. GI bleeding, ulceration or perforation; patients w/ symptoms indicative of GI disorders, history suggestive of GI ulceration, ulcerative colitis or Crohn's disease, bleeding diathesis or hematological abnormalities; history of ulcer particularly if complicated w/ hemorrhage or perforation; history of GI toxicity; concomitant w/ medications which could increase the risk of ulceration or bleeding eg, oral corticosteroids, anticoagulants (warfarin), SSRIs or antiplatelet agents (aspirin). SLE, mixed connective tissue disorders. Serious skin reactions including exfoliative dermatitis, Stevens-Johnson syndrome & toxic epidermal necrolysis. Discontinue at the 1st appearance of skin rash, mucosal lesions or any other sign of hypersensitivity. Avoid use in case of varicella. Allergic reactions including anaphylactic/anaphylactoid reactions. May reversibly inhibit platelet aggregation. Monitor precautionary measure eg, renal, hepatic function & blood counts on long-term treatment. May impair ability to drive or operate machinery. Women attempting to conceive, 1st & 2nd trimester pregnancy, lactation. Childn <18 yr. Elderly.