Gel 0.1% and Cream: Pregnancy: No information on the effects of adapalene in pregnant women is available. Consequently adapalene should not be used during pregnancy, especially during the first three months.
Lactation: It is not known whether this drug is excreted in animal or human milk. Because many drugs are excreted in human milk, caution should be exercised when Differin Gel and Differin Cream are administrated to nursing mothers. In this event, the product should not be used on the chest.