Divalgen 250/Divalgen 500

Divalgen 250/Divalgen 500

valproic acid


Akums Drug


InnoGen Pharmaceuticals
Concise Prescribing Info
Divalproex Na (equiv to valproic acid)
Primary generalized seizures; notable benefit in absence & myoclonic seizures; partial seizures. Acute manic phase of bipolar disorder & prophylaxis of migraine.
Dosage/Direction for Use
Adult Epilepsy Initially 600 mg in 2 divided doses. May be increased by 200 mg every 3 days to a usual range of 1-2 g daily, up to max of 2.5 g daily. Acute manic episodes of bipolar disorder Initially 750 mg in 2 or 3 divided doses, may be increased to 20-30 mg/kg daily, max up to 60 mg/kg daily. Prophylaxis of migraine 250 mg bid up to 1 g daily. Childn weighing >20 kg 40 mg daily in 2 divided doses, gradually increased to 20-30 mg/kg daily up to max of 35 mg/kg daily, <20 kg 20 mg/kg daily in 2 divided doses, may be increased to 40 mg/kg daily or more if necessary. Neonate Initially 20 mg/kg once daily. Maintenance: 10 mg/kg bid, 1 mth-12 yr Initially 5-7.5 mg/kg bid. Maintenance: 12.5-15 mg/kg bid. Infantile spasms Up to 30 mg/kg bid, <12 yr Usual adult dose.
May be taken with or without food.
Patients w/ preexisting liver disease or family history of severe hepatic dysfunction. Avoid use w/ other hepatotoxic drugs.
Special Precautions
Drugs that interfere w/ blood coagulation eg, aspirin or warfarin. Risk of hepatotoxicity in childn <3 yr & those w/ congenital metabolic or degenerative disorders, organic brain disease or severe seizure disorders associated w/ mental retardation; use of antiepileptics before & during the 1st 6 mth of therapy. Pancreatitis. Monitor patients for potential bleeding complications before major elective surgery. Porphyria. Lactation.
Adverse Reactions
GI disturbances; increased appetite, wt gain.
Drug Interactions
Raised blood conc w/ erythromycin. May antagonize antiepileptic activity w/ antidepressants. Increased bioavailability w/ antacids (Al & Mg hydroxides). May increase free valproate plasma conc w/ highly protein bound drugs.
MIMS Class
ATC Classification
N03AG01 - valproic acid ; Belongs to the class of fatty acid derivatives antiepileptic.
Divalgen 250 ER tab 250 mg
10's (P18/ER tab)
Divalgen 500 ER tab 500 mg
10's (P23/ER tab)
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