Pharmacology: Pharmacokinetics: Like adrenalin, dobutamine is inactive when given by mouth and it is rapidly inactivated in the body by similar process. It has a half life of about 2 minutes. Conjugates of dobutamine and its major metabolite 3-O-methyldobutamine are excreted primarily in the urine, with small amounts eliminated in the feces.
The primary mechanism of clearance of dobutamine appears to be distribution to other tissues, and not metabolism or elimination. It has a half life of about 2 minutes and plasma concentration of dobutamine reached steady state of about 10-12 minutes after the start of the infusion. Dobutamine is used mainly for the short term treatment of heart failure and any pharmacokinetic changes in this condition have no clinical implications in dosage titration.