Overdoses of Dobutamine have been reported rarely. The symptoms of toxicity include anorexia, nausea, vomiting, tremor, anxiety, palpitations, headache, shortness of breath, and angina and nonspecific chest pain. The positive inotropic and chronotropic effects of dobutamine may cause hypertension, tachyarrhythmias, myocardial ischemia and ventricular fibrillation. Hypotension may result from vasodilatation.
The duration of action of dobutamine hydrochloride is generally short (half-life, approximately 2 minutes).
Temporarily discontinue dobutamine until the patient's condition stabilizes. The patient should be monitored and any appropriate resuscitative measures initiated promptly.
Forced diuresis, peritoneal dialysis, hemodialysis, or charcoal hemoperfusion have not been established as beneficial for an overdose of dobutamine hydrochloride.
If the product is ingested, unpredictable absorption may occur from the mouth and gastrointestinal tract.