Drug interactions associated with Aceclofenac are similar to those observed with other NSAIDs. Aceclofenac may increase the plasma concentration of lithium & digitoxin and methotrexate. Concominant use with diuretics may inhibit the activity of diuretics. The activity of anticoagulant may be entranced when used concomitantly with aceclofenac. Convulsion may occur due to interaction between quinolones and NSAID's. Coadministration of aceclofenac with other NSAID's and corticosteroids are to be avoided due to increased incidence of side effects. The risk of Paracetamol toxicity may be increased in patients receiving other potentially hepatotoxic drugs or drugs that induce hepatic microsomal enzymes. Coadministration of paracetamol with rifampicin, isoniazid, chloramphenicol, antiepileptic drugs and antiviral drugs is to be avoided. Metoclopromide may increase the absorption of paracetamol where as excretion and plasma concentration may be altered when co administered with probenecid. Cholestyramine also reduces the absorption of paracetamol.