Domne

Domne

domperidone

Manufacturer:

Raptakos Brett

Distributor:

Raptakos Brett
Concise Prescribing Info
Contents
Domperidone
Indications/Uses
Anti-emetic for short-term treatment of nausea & vomiting of various etiologies, including such associated w/ cancer therapy & nausea & vomiting associated by levodopa or bromocriptine therapy for Parkinsonism. Used for its prokinetic action for dyspepsia & has been tried in diabetic gastroparesis.
Dosage/Direction for Use
Chronic indigestion Adult 10 mL tid, 15-30 min before meals. If needed, 10 mL before bedtime. Childn 2.5 mL/10 kg before meals. If needed, 2.5 mL before bedtime. Nausea or vomiting Adult 20 mL tid, 15-30 min before meals. If needed, 10 mL before bedtime. Childn >5 yr 5 mL/10 kg before meals. If needed, 2.5 mL before bedtime.
Administration
Should be taken on an empty stomach.
Contraindications
Hypersensitivity. Should not be used whenever stimulation of gastric motility is to be avoided or could be harmful eg, GI hemorrhage, obstruction or perforation, epilepsy, pheochromocytoma, extrapyramidal symptoms. Pregnancy.
Special Precautions
Not recommended for chronic administration or for routine prophylaxis of post-op nausea & vomiting. Patients at risk of fluid retention & on prolonged therapy. Hepatic & renal impairment. Lactation. Elderly.
Adverse Reactions
Allergic reactions eg, rash or urticaria; abdominal cramps; reversible raised serum prolactin levels. Neurological side effects in neonates.
Drug Interactions
Reduced hypoprolactinaemic effect of bromocriptine. Inhibited antidyspeptic effects w/ anticholinergic drugs. Antagonized effect w/ anti-muscarinic agents & opioid analgesics. Suppressed peripheral effects of dopaminergic agonists. Can influence absorption of concomitantly orally administered medicines particularly SR or EC formulations. May interfere serum prolactin levels w/ other hypoprolactinaemic agents & some diagnostic tests. Lowered oral bioavailability w/ antacids & antisecretory agents. Decreased oral bioavailability w/ cimetidine or Na carbonate. Impaired absorption w/ reduced gastric acidity.
ATC Classification
A03FA03 - domperidone ; Belongs to the class of propulsives. Used in the treatment of functional gastrointestinal disorders.
Presentation/Packing
Form
Domne oral susp 1 mg/mL
Packing/Price
30 mL x 1's
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