Dormid Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Midazolam HCl

Indications/Uses

Premed to provide sedation for minor surgical procedures eg, dental treatment & endoscopy. Induction of general anesth. Continuous sedation in intensive care patients. To confirm the diagnosis of hysterical paralysis. Advanced cancer & interactable dyspnoea to relieve air hunger & sedate dying patients who have unrelieved distress. To relieve pain associated w/ skeletal muscle spasm.

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Dosage/Direction for Use

Individualized dosage. Dental & minor surgical procedures 2.5-7.5 mg (about 70 mcg/kg) IV. Initially 2 mg over 30 sec w/ further incremental doses of 0.5-1 mg at 2-min intervals. Induction of anaesth 200 mcg/kg slow IV in premed patient & at least 300 mcg/kg not in premed. Childn >7 yr 150 mcg/kg. Patient in intensive care requiring continuous sedation Initial loading dose: 30-300 mcg/kg IV infusion over 5 min. Maintenance: 20-200 mcg/kg/hr or 1-2 mg IV bolus. Premedicant before surgery 5 mg (70-100 mcg/kg) IM 30-60 min.

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Overdosage

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Contraindications

Hypersensitivity. Myasthenia gravis, patients in shock or coma, acute alcoholic intoxication w/ depression of vital signs, acute narrow-angle glaucoma.

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Special Precautions

Continuous monitoring of cardioresp function & resuscitation procedures; early signs of underventilation or apnea. Resp depression, apnea, resp arrest &/or cardiac arrest; hypoxic encephalopathy. Patients w/ preexisting resp insufficiency. Dependence in patients w/ history of alcohol or drug abuse & marked personality disorders. Hepatic & renal insufficiency. Very ill patients, high-risk surgical patients; patients w/ limited pulmonary reserve. Neonates. Pregnancy. Elderly.

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Adverse Reactions

Resp depression, hypotension, cardiac arrest; pain, tenderness, thrombophlebitis; hiccups.

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Drug Interactions

Enhanced sedation or resp & CV depression w/ CNS depressants eg, alcohol, antidepressants, antihistamines, antipsychotic, general anesth or analgesics; cisapride. Aspirin shortens time to induce anesth. Reduced clearance w/ fentanyl, cimetidine. May diminish analgesic effects of sufentanil. Increased peak plasma conc w/ erythromycin & blood conc w/ ciprofloxacin. Decreased t_½ w/ rifampicin. Increased intensity & duration of action w/ ketoconazole & itraconazole. Avoid concomitant use w/ HIV-PIs. Peak plasma conc is doubled & prolonged elimination t_½w/ diltiazem & verapamil. Synergistic interaction between thiopental; methohexital & propofol. Reduced conc of halothane for anesth. Reversed by benzodiazepines antagonist flumezenil. Clozapine, roxithromycin.

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Storage

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Description

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Action

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MIMS Class

Hypnotics & Sedatives

ATC Classification

N05CD08 - midazolam ; Belongs to the class of benzodiazepine derivatives. Used as hypnotics and sedatives.

Regulatory Classification

DD, Rx

Presentation/Packing

Form

Dormid soln for inj 1 mg/mL

Packing/Price

5 mL x 10 × 1's

Form

Dormid soln for inj 5 mg/mL

Packing/Price

3 mL x 5 × 1's

Dormid

midazolam

Manufacturer:

PT Novell

Distributor:

Endure Medical